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Home - Products - GPCR/G Protein - Antibacterial - PA-824

PA-824

CAS No. 187235-37-6

PA-824( PA824 | PA 824 | Pretomanid | (S)-PA 824 )

Catalog No. M12898 CAS No. 187235-37-6

A anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid; exhibits bactericidal activity against both replicating and static M. tuberculosis (MIC: 0.015-0.25 ug/mL).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 59 In Stock
25MG 86 In Stock
50MG 112 In Stock
100MG 172 In Stock
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Biological Information

  • Product Name
    PA-824
  • Note
    Research use only, not for human use.
  • Brief Description
    A anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid; exhibits bactericidal activity against both replicating and static M. tuberculosis (MIC: 0.015-0.25 ug/mL).
  • Description
    A anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid; exhibits bactericidal activity against both replicating and static M. tuberculosis (MIC: 0.015-0.25 ug/mL); shows potent bactericidal activity against MDR M. tuberculosis and promising oral activity in animal infection models.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PA824 | PA 824 | Pretomanid | (S)-PA 824
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    tuberculosis
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    187235-37-6
  • Formula Weight
    359.2574
  • Molecular Formula
    C14H12F3N3O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 33 mg/mL
  • SMILES
    FC(F)(F)OC1=CC=C(C=C1)CO[C@H]2CN3C(OC2)=NC([N+]([O-])=O)=C3
  • Chemical Name
    5H-Imidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-, (6S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Stover CK, et al. Nature. 2000 Jun 22;405(6789):962-6. 2. Tyagi S, et al. Antimicrob Agents Chemother. 2005 Jun;49(6):2289-93. 3. Lenaerts AJ, et al. Antimicrob Agents Chemother. 2005 Jun;49(6):2294-301.
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