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ROC-325
CAS No. 1859141-26-6
ROC-325( ROC 325 | ROC325 )
Catalog No. M12869 CAS No. 1859141-26-6
ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 29 | In Stock |
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| 5MG | 45 | In Stock |
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| 10MG | 74 | In Stock |
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| 25MG | 157 | In Stock |
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| 50MG | 246 | In Stock |
|
| 100MG | 384 | In Stock |
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| 200MG | 548 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameROC-325
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NoteResearch use only, not for human use.
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Brief DescriptionROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy.
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DescriptionROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy; exhibits superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in different cancer cell lines, including accumulation of autophagosomes with undegraded cargo, lysosomal deacidification, p62 stabilization, and disruption of autophagic flux; antagonizes RCC growth and survival in an ATG5/7-dependent manner, induces apoptosis and exhibited favorable selectivity; significantly more effective at inhibiting tumor progression than HCQ, and inhibited autophagy in vivo.
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In Vitro——
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In Vivo——
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SynonymsROC 325 | ROC325
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1859141-26-6
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Formula Weight503.061
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Molecular FormulaC28H27ClN4OS
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Purity>98% (HPLC)
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SolubilityDMSO : 32 mg/mL 63.61 mM; H2O : < 0.1 mg/mL
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SMILESO=C1C2=C(C(C)=CC=C2NCCN(C)CCNC3=C(C=CC(Cl)=C4)C4=NC=C3)SC5=CC=CC=C51
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Chemical Name1-((2-((2-((7-chloroquinolin-4-yl)amino)ethyl)(methyl)amino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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2,2-Dihydroxy chalco...
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PD146176
PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.?PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
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Pitavastatin
Pitavastatin (NK-104) is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase, effectively inhibiting cholesterol synthesis from acetic acid in HepG2 cells with an IC50 of 5.8 nM.
