Cart
sales@molnova.com
SirReal2 (b)
CAS No. 1848251-24-0
SirReal2 (b)( MZ25 | MZ-25 | SirReal 2 )
Catalog No. M12854 CAS No. 1848251-24-0
SirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameSirReal2 (b)
-
NoteResearch use only, not for human use.
-
Brief DescriptionSirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435 uM.
-
DescriptionSirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435 uM; displays >1,000-fold more potently than Sirt1, Sirt3, Sirt4, Sirt5 and Sirt6; increases α-tubulin acetylation in HeLa cells, significantly results in a dose-dependent depletion of BubR1.
-
In Vitro——
-
In Vivo——
-
SynonymsMZ25 | MZ-25 | SirReal 2
-
PathwayChromatin/Epigenetic
-
TargetSirtuin
-
RecptorSirtuin
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1848251-24-0
-
Formula Weight420.549
-
Molecular FormulaC22H20N4OS2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC=CC4=CC=CC=C43)C
-
Chemical Name2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Rumpf T, et al. Nat Commun. 2015 Feb 12;6:6263.
2. Schiedel M, et al. Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2252-6.
molnova catalog
related products
-
Inauhzin
Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity.
-
lithospermic acid B
lithospermic acid B is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation anticoagulant and antithrombotic effect.
-
Tenovin-6 Hydrochlor...
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator.
