Cart
sales@molnova.com
SirReal2 (b)
CAS No. 1848251-24-0
SirReal2 (b)( MZ25 | MZ-25 | SirReal 2 )
Catalog No. M12854 CAS No. 1848251-24-0
SirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameSirReal2 (b)
-
NoteResearch use only, not for human use.
-
Brief DescriptionSirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435 uM.
-
DescriptionSirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435 uM; displays >1,000-fold more potently than Sirt1, Sirt3, Sirt4, Sirt5 and Sirt6; increases α-tubulin acetylation in HeLa cells, significantly results in a dose-dependent depletion of BubR1.
-
In Vitro——
-
In Vivo——
-
SynonymsMZ25 | MZ-25 | SirReal 2
-
PathwayChromatin/Epigenetic
-
TargetSirtuin
-
RecptorSirtuin
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1848251-24-0
-
Formula Weight420.549
-
Molecular FormulaC22H20N4OS2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC=CC4=CC=CC=C43)C
-
Chemical Name2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Rumpf T, et al. Nat Commun. 2015 Feb 12;6:6263.
2. Schiedel M, et al. Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2252-6.
molnova catalog
related products
-
SRT 3025
SRT3025 is a potent, orallu actuve SIRT1 activator that activates wild-type Sirt1 protein.
-
EX 527 (Selisistat)
EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3.
-
SRT 1720 dihydrochlo...
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).
