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CPI 0610
CAS No. 1845726-14-8
CPI 0610( CPI0610 )
Catalog No. M12851 CAS No. 1845726-14-8
CPI 0610 is a potent, selective, and cell-active BET bromodomain inhibitor with IC50 of 39 nM for BRD4-BD1 in TR-FRET assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCPI 0610
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NoteResearch use only, not for human use.
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Brief DescriptionCPI 0610 is a potent, selective, and cell-active BET bromodomain inhibitor with IC50 of 39 nM for BRD4-BD1 in TR-FRET assay.
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DescriptionCPI 0610 is a potent, selective, and cell-active BET bromodomain inhibitor with IC50 of 39 nM for BRD4-BD1 in TR-FRET assay; shows remarkably selectivity, over the bromodomains of CBP, BRD9, BRPF1, PCAF, BRG1, ATAD2, TRIM24, BRD8; has an IC50 of 0.18 uM in MYC RNA expression assay; demonstrates antitumor efficacy in an MV-4-11 mouse xenograft model.
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In Vitro——
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In Vivo——
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SynonymsCPI0610
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBromodomain
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Research Area——
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Indication——
Chemical Information
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CAS Number1845726-14-8
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Formula Weight365.817
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Molecular FormulaC20H16ClN3O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[e]isoxazolo[5,4-c]azepin-4-yl)acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Albrecht BK, et al. J Med Chem. 2016 Feb 25;59(4):1330-9.
2. Siu KT, et al. Leukemia. 2017 Jan 3. doi: 10.1038/leu.2016.355.
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NI-57
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