LEM-14( LEM14 | LEM 14 | LEM-14 )

Catalog No. M12786 CAS No. 1814881-70-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

LEM-14
Note

Research use only, not for human use.
Brief Description

LEM-14 is a specific inhibitor of histone lysine methyltransferase NSD2 (MMSET/WHSC1) with in vitro IC50 of 132 uM.
Description

LEM-14 is a specific inhibitor of histone lysine methyltransferase NSD2 (MMSET/WHSC1) with in vitro IC50 of 132 uM, and that is inactive against the closely related NSD1 and NSD3.
In Vitro

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In Vivo

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Synonyms

LEM14 | LEM 14 | LEM-14
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

——
Indication

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CAS Number

1814881-70-3
Formula Weight

478.567
Molecular Formula

C25H26N4O4S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (104.48 mM)
SMILES

O=C1C(C2=C(CCCC2)S3)=C3N=C(CN4CCN(C([C@@H](CC5=C6C=CC=C5)OC6=O)=O)CC4)N1
Chemical Name

(R)-2-((4-(1-oxoisochromane-3-carbonyl)piperazin-1-yl)methyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

1. Shen Y, et al. Biochem Biophys Res Commun. 2018 Nov 21. pii: S0006-291X(18)32443-4.

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