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Almotriptan Malate
CAS No. 181183-52-8
Almotriptan Malate( PNU 180638E )
Catalog No. M12781 CAS No. 181183-52-8
Almotriptan Malate is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 25MG | 42 | In Stock |
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| 50MG | 77 | In Stock |
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| 100MG | 124 | In Stock |
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| 200MG | 183 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAlmotriptan Malate
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NoteResearch use only, not for human use.
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Brief DescriptionAlmotriptan Malate is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults.
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DescriptionAlmotriptan Malate is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults.
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In Vitro——
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In Vivo——
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SynonymsPNU 180638E
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT1B/1D
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number181183-52-8
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Formula Weight469.55
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Molecular FormulaC17H25N3O2S·C4H6O5
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Purity>98% (HPLC)
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SolubilityEthanol: 53 mg/mL (112.87 mM); DMSO: 94 mg/mL (200.19 mM)
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SMILESCN(CCC1=CNC2=C1C=C(CS(=O)(N3CCCC3)=O)C=C2)C.O=C(O)C(O)CC(O)=O
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Chemical NameN,N-dimethyl-2-(5-((pyrrolidin-1-ylsulfonyl)methyl)-1H-indol-3-yl)ethan-1-amine 2-hydroxysuccinate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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4i
4i is a 5-HT3 receptor antagonist,It modulates the serotonergic system.
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PRX-07034
PRX-07034 is a selective antagonist of 5-HT6 receptor. It has cognition and memory-enhancing properties and potently decreases food intake and body weight in rodents.?PRX-07034 is both a potent (Ki = 4-8 nM) and highly selective 5-HT(6) receptor antagonist (≥100-fold selectivity for the 5-HT(6) receptor compared to 68 other GPCRs, ion channels, and transporters, except D(3) (Ki = 71 nM) and 5-HT(1B) (Ki = 260 nM) receptors.
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Hyperforin
Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels and triggers adipose tissue thermogenesis via the Dlat-AMPK signaling axis to suppress obesity. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod -induced psoriasis-like mice model.
