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LDK1229
CAS No. 1800285-55-5
LDK1229( LDK 1229 )
Catalog No. M12734 CAS No. 1800285-55-5
LDK1229 is a novel potent, selective cannabinoid CB1 receptor inverse agonist with Ki of 220 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameLDK1229
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NoteResearch use only, not for human use.
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Brief DescriptionLDK1229 is a novel potent, selective cannabinoid CB1 receptor inverse agonist with Ki of 220 nM.
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DescriptionLDK1229 is a novel potent, selective cannabinoid CB1 receptor inverse agonist with Ki of 220 nM; exhibits 3-fold relative selectivity for the CB1 over CB2, exhibits efficacy comparable with SR141716A in antagonizing the basal G protein coupling activity of CB1; increases cell surface localization of CB1 and structurally distinct from the first-generation CB1 inverse agonists.
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In Vitro——
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In Vivo——
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SynonymsLDK 1229
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PathwayGPCR/G Protein
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TargetCannabinoid Receptor
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RecptorCannabinoid Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1800285-55-5
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Formula Weight434.956
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Molecular FormulaC24H29ClF2N2O
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)(cyclohexyl)methanone hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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COR659
COR659 is a 2-acylaminothiophene derivative able to suppress alcohol and chocolate self-administration in rats, likely via positive allosteric modulation of the GABAB receptor and antagonism/inverse agonism at the cannabinoid CB1 receptor.
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CB2R/FAAH modulator-...
CB2R/FAAH modulator-3 (compound 27) is a modulator targeting CB2R and FAAH, acting as a CB2R agonist with a Ki value of 20.1 nM and a CB1R agonist with a Ki value of 67.6 nM, while inhibiting FAAH with an IC50 value of 3.4 μM.
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Hemopressin (human, ...
Bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity in vivo.
