NKP-608( NK 608 | NK608 )

Catalog No. M12675 CAS No. 177707-12-9

A non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM.

Purity : >98% (HPLC)

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Biological Information

Product Name

NKP-608
Note

Research use only, not for human use.
Brief Description

A non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM.
Description

A non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM; exhibits an anxiolytic-like effect in the social interaction and social exploration test in rats; orally active.Irritable Bowel Syndrome Discontinued.
In Vitro

——
In Vivo

——
Synonyms

NK 608 | NK608
Pathway

GPCR/G Protein
Target

Neurokinin Receptor
Recptor

Neurokinin Receptor
Research Area

Other Indications
Indication

Irritable Bowel Syndrome

Chemical Information

CAS Number

177707-12-9
Formula Weight

619.9846
Molecular Formula

C31H24ClF6N3O2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(C1=CC=NC2=CC=CC=C12)N[C@@H]3C[C@@H](CC4=CC=C(Cl)C=C4)N(C(C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O)CC3
Chemical Name

4-Quinolinecarboxamide, N-[(2R,4S)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-[(4-chlorophenyl)methyl]-4-piperidinyl]-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Gentsch C, et al. Behav Brain Res. 2002 Jul 18;133(2):363-8. 2. Vassout A, et al. Regul Pept. 2000 Dec 22;96(1-2):7-16. 3. Coulson FR, et al. Inflamm Res. 2002 Jul;51(7):317-23.

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