Valganciclovir hydrochloride( Ro 107-9070/194 | Valcyte )

Catalog No. M12657 CAS No. 175865-59-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Valganciclovir hydrochloride
Note

Research use only, not for human use.
Brief Description

Valganciclovir (hydrochloride), the L-valyl ester of ganciclovir, is actually a prodrug for ganciclovir.
Description

Valganciclovir (hydrochloride), the L-valyl ester of ganciclovir, is actually a prodrug for ganciclovir. Valganciclovir is an antiviral medication used to treat cytomegalovirus infections.
In Vitro

Cell Viability Assay Cell Line:A549 cells Concentration:500 μM Incubation Time:5 days, 7days Result:Showed EC50 values ranged from 120.5 μM (Ad4) to 244.4 μM (Ad6).Showed IC50 values was calculated to be 11.74 mM at 7 days post-infection.
In Vivo

Animal Model:Immunosuppressed hamstersDosage:200 mg/kg Administration:Oral gavage (p.o.)Result:Resulted in significantly smaller magnitude of weight loss for all groups.Reduced the liver pathology.
Synonyms

Ro 107-9070/194 | Valcyte
Pathway

Others
Target

Other Targets
Recptor

CMV
Research Area

Infection
Indication

——

CAS Number

175865-59-5
Formula Weight

390.82
Molecular Formula

C14H23ClN6O5
Purity

>98% (HPLC)
Solubility

Water: 78 mg/mL (199.58 mM); DMSO: 78 mg/mL (199.58 mM)
SMILES

CC(C)[C@H](N)C(OCC(OCN1C=NC2=C1NC(N)=NC2=O)CO)=O.[H]Cl
Chemical Name

[2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] (2S)-2-amino-3-methylbutanoate hydrochloride

1.Sugawara M, et al. J Pharm Sci, 2000, 89(6), 781-789.

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