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CM 346
CAS No. 173352-21-1
CM 346( Obenoxazine )
Catalog No. M12632 CAS No. 173352-21-1
Afobazole (CM346) is an anxiolytic drug; produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 75 | In Stock |
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| 5MG | 52 | In Stock |
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| 10MG | 92 | In Stock |
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| 25MG | 207 | In Stock |
|
| 50MG | 300 | In Stock |
|
| 100MG | 449 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCM 346
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NoteResearch use only, not for human use.
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Brief DescriptionAfobazole (CM346) is an anxiolytic drug; produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions.
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DescriptionAfobazole (CM346) is an anxiolytic drug; produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions.(In Vitro):Afobazole's mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Afobazole has found little clinical use outside of Russia and has not been evaluated by the FDA.
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In VitroAfobazole's mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Afobazole has found little clinical use outside of Russia and has not been evaluated by the FDA.
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In Vivo——
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SynonymsObenoxazine
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number173352-21-1
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Formula Weight307.41
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Molecular FormulaC15H21N3O2S
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Purity>98% (HPLC)
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SolubilitySoluble in DMSO
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SMILESCCOC1=CC=C2C(N=C(SCCN3CCOCC3)N2)=C1
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Chemical Name4-(2-((5-ethoxy-1H-benzo[d]imidazol-2-yl)thio)ethyl)morpholine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Behensky AA, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):458-67.
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