Autophinib( Autophinib )

Catalog No. M12507 CAS No. 1644443-47-9

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Product Name

Autophinib
Note

Research use only, not for human use.
Brief Description

Autophinib is a novel, potent autophagy inhibitor that inhibits autophagy induced by starvation (IC50=90 nM) or rapamycin (IC50=40 nM) by targeting the lipid kinase VPS34 (IC50=19 nM).
Description

Autophinib is a novel, potent autophagy inhibitor that inhibits autophagy induced by starvation (IC50=90 nM) or rapamycin (IC50=40 nM) by targeting the lipid kinase VPS34 (IC50=19 nM); inhibits LC3 lipidation to form LC3-II, also inhibits p62 degradation dose-dependently in starved MCF7-LC3 cells; an ATP-competitive inhibitor of VPS34 but not other lipid kinases, mTOR and TBK1.
In Vitro

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In Vivo

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Synonyms

Autophinib
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

rapamycin-inducedautophagy|starvation-inducedautophagy|VPS34
Research Area

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Indication

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CAS Number

1644443-47-9
Formula Weight

346.731
Molecular Formula

C14H11ClN6O3
Purity

>98% (HPLC)
Solubility

DMSO: 64 mg/mL (184.6 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=[N+](C1=CC=C(OC2=NC(Cl)=CC(NC3=NNC(C)=C3)=N2)C=C1)[O-]
Chemical Name

6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine

1. Robke L, et al. Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8153-8157.

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