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ANT431

CAS No. 1639972-90-9

ANT431( ANT 431 | ANT-431 )

Catalog No. M12483 CAS No. 1639972-90-9

ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2.

Purity : >98% (HPLC)

COA

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HNMR

HPLC

MSDS

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Biological Information

Product Name

ANT431
Note

Research use only, not for human use.
Brief Description

ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2.
Description

ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively); potentiate the activity of meropenem (MEM) against a broad range of MBL-producing carbapenem-resistant Enterobacteriaceae (CRE), restore its efficacy against an Escherichia coli NDM-1 strain in a murine thigh infection model.
In Vitro

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In Vivo

——
Synonyms

ANT 431 | ANT-431
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

Chemical Information

CAS Number

1639972-90-9
Formula Weight

285.292
Molecular Formula

C9H7N3O4S2
Purity

>98% (HPLC)
Solubility

——
SMILES

C1=CC(=CN=C1)S(=O)(=O)NC2=C(N=CS2)C(=O)O
Chemical Name

5-(pyridine-3-sulfonamido)thiazole-4-carboxylic acid

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Everett M, et al. Antimicrob Agents Chemother. 2018 Mar 12. pii: AAC.00074-18.

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