CHDI-390576( CHDI390576 )

Catalog No. M12446 CAS No. 1629729-98-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

CHDI-390576
Note

Research use only, not for human use.
Brief Description

CHDI-390576 (CHDI390576) is a potent, cell permeable and CNS penetrant class IIa HDAC inhibitor.
Description

CHDI-390576 (CHDI390576) is a potent, cell permeable and CNS penetrant class IIa HDAC inhibitor with IC50 of 54/60/31/50 nM for HDAC4/5/7/9, respectively; displays >500-fold selectivity over class I HDAC/1/2/3 and 150-fold selectivity over HDAC8 and the class IIb HDAC6; CHDI-390576 was well-tolerated and showed no significant effect on passive observations, responses to manipulations, body weight, or body temperature in PK studies.
In Vitro

The affinity (Kd) of CHDI-390576 to the catalytic domain of immobilized HDAC4 is 80 nM.CHDI-390576 inhibits class I HDACs (1, 3, 8) and class IIb HDAC6 isoforms with IC50s of 39.7μM, 25.8 μM, 9.1 μM, 6.2 μM, respectively.
In Vivo

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Synonyms

CHDI390576
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

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Indication

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CAS Number

1629729-98-1
Formula Weight

391.326
Molecular Formula

C19H13F4N3O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (638.86 mM)
SMILES

O=C(NO)C(C1=CC=CC=C1F)C2=CC=C(C3=NC=C(C(F)(F)F)C=N3)C=C2
Chemical Name

2-(2-fluorophenyl)-N-hydroxy-2-(4-(5-(trifluoromethyl)pyrimidin-2-yl)phenyl)acetamide

1. Luckhurst CA, et al. Bioorg Med Chem Lett. 2018 Nov 13. pii: S0960-894X(18)30858-8. doi: 10.1016/j.bmcl.2018.11.009.

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