MW181 dihydrochloride

Research use only, not for human use.

MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM.

MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ; suppresses p38α MAPK activation, reduces tau phosphorylation, and decreases proinflammatory cytokine production, suppresses LPS-induced increases in mouse brain IL-1β, TNFα, IL-6, IL-10, and CXCL1 in mice, significantly increases synaptophysin protein expression and prevents cognitive impairment in the aged hTau mice.

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MW01-10-181SRM

MAPK/ERK Signaling

p38 MAPK

p38 MAPK

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1628503-08-1

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>98% (HPLC)

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N,N-dimethyl-6-(naphthalen-1-yl)-5-(pyridin-4-yl)pyridazin-3-amine dihydrochloride

(-20℃)

With Ice Pack

≥ 2 years