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WAY-100635
CAS No. 162760-96-5
WAY-100635( WAY 100635 | WAY100635 )
Catalog No. M12413 CAS No. 162760-96-5
A potent and selective 5-HT1A receptor antagonist; also acts as potent full agonist at the D4 receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 53 | Get Quote |
|
| 50MG | 320 | Get Quote |
|
| 100MG | 566 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameWAY-100635
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective 5-HT1A receptor antagonist; also acts as potent full agonist at the D4 receptor.
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DescriptionA potent and selective 5-HT1A receptor antagonist; also acts as potent full agonist at the D4 receptor; completely prevents not only the hyperpolarization, with an IC50 of 1.3 nM, but also the decrease in membrane input resistance produced by 5-HT and 5-carboxamidotryptamine with IC50 of 22.5 μM and 50 nM, respectively. Anxiety Phase 1 Discontinued.
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In VitroThe functional properties and binding affinities of WAY-100635 are evaluated in HEK 293 cells stably expressing dopamine D2L or D4.4 receptors.WAY-100635 displays 940, 370, and 16 nM binding affinities at D2L, D3, and D4.2 receptors, respectively. Saturation analyses demonstrat that the Kd of [3H] WAY-100635 at D4.2 receptors is 2.4 nM. WAY-100635 is potent agonist in HEK-D4.4 cells with EC50 of 9.7 nM. WAY-100635 possesses high affinity for D4.4 receptor (3.3 nM) .
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In VivoWAY-100635 (1 mg/kg; subcutaneous injection; male Sprague-Dawley rats) treatment abolishes the reduction of the severity of abstinence signs induced by Rhodiola rosea administration in nicotine-dependent rat. Animal Model:Male Sprague-Dawley rats (220-240 g)Dosage:1 mg/kg Administration:Subcutaneous injection (Pharmacokinetic study)Result:Reduced total abstinence score, increased immobility time and the burying behavior was increased.
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SynonymsWAY 100635 | WAY100635
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PathwayGPCR/G Protein
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research AreaNeurological Disease
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IndicationAnxiety
Chemical Information
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CAS Number162760-96-5
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Formula Weight422.563
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Molecular FormulaC25H34N4O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(C1CCCCC1)N(CCN2CCN(C3=CC=CC=C3OC)CC2)C4=NC=CC=C4
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Chemical NameN-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cyclohexanecarboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Corradetti R, et al. J Pharmacol Exp Ther. 1996 Aug;278(2):679-88.
2. Fornal CA, et al. J Pharmacol Exp Ther. 1996 Aug;278(2):752-62.
3. García G, et al. Eur J Med Chem. 2014 Oct 6;85:795-806.
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