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AZD-3759
CAS No. 1626387-80-1
AZD-3759( AZD-3759 )
Catalog No. M12405 CAS No. 1626387-80-1
A potent, oral active, BBB-penetrating EGFR inhibitor (IC50=7.2 nM, L858R pEGFR).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 35 | In Stock |
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| 25MG | 56 | In Stock |
|
| 50MG | 80 | In Stock |
|
| 100MG | 125 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZD-3759
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, oral active, BBB-penetrating EGFR inhibitor (IC50=7.2 nM, L858R pEGFR).
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DescriptionA potent, oral active, BBB-penetrating EGFR inhibitor (IC50=7.2 nM, L858R pEGFR); fully penetrate the blood-brain barrier (BBB), with equal free concentrations in the blood, cerebrospinal fluid, and brain tissue; causes tumor regression in subcutaneous xenograft, leptomeningeal metastasis (LM), and brain metastasis (BM) lung cancer models and prevents the development of BM in nude mice.Lung Cancer Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsAZD-3759
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR(exon19Del)|EGFR(L858R)|EGFR(WT)
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number1626387-80-1
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Formula Weight459.9011
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Molecular FormulaC22H23ClFN5O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(N1[C@H](C)CN(C)CC1)OC2=CC3=C(NC4=CC=CC(Cl)=C4F)N=CN=C3C=C2OC
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Chemical Name1-Piperazinecarboxylic acid, 2,4-dimethyl-, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester, (2R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zeng Q, et al. J Med Chem. 2015 Oct 22;58(20):8200-15.
2. Yang Z, et al. Sci Transl Med. 2016 Dec 7;8(368):368ra172.
3. Tan CS, et al. Lung Cancer. 2016 Mar;93:59-68.
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