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Fingolimod
CAS No. 162359-55-9
Fingolimod( FTY720 free base | FTY 720 free base | FTY-720 free base )
Catalog No. M12397 CAS No. 162359-55-9
An immunomodulatory agent can be phosphorylated by SphK, then functions as a potent agonist of S1P receptors (S1P1/3/4/5) with EC50 of 0.3-5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | 45 | In Stock |
|
| 500MG | 113 | In Stock |
|
| 1G | 142 | In Stock |
|
Biological Information
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Product NameFingolimod
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NoteResearch use only, not for human use.
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Brief DescriptionAn immunomodulatory agent can be phosphorylated by SphK, then functions as a potent agonist of S1P receptors (S1P1/3/4/5) with EC50 of 0.3-5 nM.
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DescriptionAn immunomodulatory agent can be phosphorylated by SphK, then functions as a potent agonist of S1P receptors (S1P1/3/4/5) with EC50 of 0.3-5 nM; has no affitnity for S1P2; alters lymphocyte trafficking and inhibits lymphocyte recirculation.Multiple Sclerosis Approved.
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In Vitro——
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In Vivo——
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SynonymsFTY720 free base | FTY 720 free base | FTY-720 free base
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PathwayGPCR/G Protein
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TargetLysophospholipid Receptor
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RecptorLysophospholipid Receptor
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Research AreaInflammation/Immunology
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IndicationMultiple Sclerosis
Chemical Information
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CAS Number162359-55-9
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Formula Weight307.4708
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Molecular FormulaC19H33NO2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESOCC(CCC1=CC=C(CCCCCCCC)C=C1)(N)CO
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Chemical Name1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mandala S, et al. Science. 2002 Apr 12;296(5566):346-9.
2. Suzuki S, et al. Transplantation. 1996 Jan 27;61(2):200-5.
3. Billich A, et al. J Biol Chem. 2003 Nov 28;278(48):47408-15.
4. Forrest M, et al. J Pharmacol Exp Ther. 2004 May;309(2):758-68.
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