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CPI-1205
CAS No. 1621862-70-1
CPI-1205( CPI 1205 | CPI1205 )
Catalog No. M12387 CAS No. 1621862-70-1
A highly potent, selective EZH2 inhibitor with biochemical IC50 of 2 nM, cellular EC50 of 32 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 449 | In Stock |
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| 2MG | 117 | In Stock |
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| 5MG | 212 | In Stock |
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| 10MG | 312 | In Stock |
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| 25MG | 528 | In Stock |
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| 50MG | 728 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCPI-1205
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NoteResearch use only, not for human use.
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Brief DescriptionA highly potent, selective EZH2 inhibitor with biochemical IC50 of 2 nM, cellular EC50 of 32 nM.
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DescriptionA highly potent, selective EZH2 inhibitor with biochemical IC50 of 2 nM, cellular EC50 of 32 nM; demonstrates modest selectivity over EZH1 (IC50=52 nM), and a clean selectivity profile against 30 other histone or DNA methyltransferases; exhibits robust antitumor effects in a Karpas-422 xenograft model (at 160 mg/kg BID).Prostate Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsCPI 1205 | CPI1205
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research AreaCancer
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IndicationProstate Cancer
Chemical Information
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CAS Number1621862-70-1
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Formula Weight518.57
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Molecular FormulaC27H33F3N4O3
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Purity>98% (HPLC)
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Solubility——
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SMILESC[C@@H](N1C2=C(C(C(NCC3=C(C=C(NC3=O)C)OC)=O)=C1C)C=CC=C2)C4CCN(CC(F)(F)F)CC4
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Chemical Name(R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Vaswani RG, et al. J Med Chem. 2016 Nov 10;59(21):9928-9941.
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