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Tucidinostat
CAS No. 1616493-44-7
Tucidinostat( Chidamide | HBI-8000 | CS055 )
Catalog No. M12363 CAS No. 1616493-44-7
Tucidinostat (Chidamide, HBI-8000, CS055) is a novel histone deacetylase (HDAC) inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 55 | In Stock |
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| 5MG | 55 | In Stock |
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| 10MG | 87 | In Stock |
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| 25MG | 162 | In Stock |
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| 50MG | 258 | In Stock |
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| 100MG | 412 | In Stock |
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| 200MG | 578 | In Stock |
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| 500MG | 860 | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTucidinostat
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NoteResearch use only, not for human use.
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Brief DescriptionTucidinostat (Chidamide, HBI-8000, CS055) is a novel histone deacetylase (HDAC) inhibitor.
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DescriptionTucidinostat (Chidamide, HBI-8000, CS055) is a novel histone deacetylase (HDAC) inhibitor with IC50 of 95/160/67/733/78/432 nM for HDAC1/2/3/8/10/11, respectively; shows no activity against Class IIa HDAC4/4/7/9 and HDAC6; demonstrates significant and broad spectrum in vitro and in vivo antitumor activity, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.Blood Cancer Approved.
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In Vitro——
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In Vivo——
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SynonymsChidamide | HBI-8000 | CS055
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC1|HDAC2|HDAC3|HDAC10
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number1616493-44-7
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Formula Weight390.418
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Molecular FormulaC22H19FN4O2
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Purity>98% (HPLC)
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SolubilityEthanol: 1 mg/mL Water: InsolubleDMSO: 50 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C(NC1=CC=C(F)C=C1N)C2=CC=C(CNC(/C=C/C3=CC=CN=C3)=O)C=C2
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Chemical NameN-(2-amino-4-fluorophenyl)-4-[[[(E)-3-pyridin-3-ylprop-2-enoyl]amino]methyl]benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ning ZQ, et al. Cancer Chemother Pharmacol. 2012 Apr;69(4):901-9.
2. Gong K, et al. Biochem J. 2012 May 1;443(3):735-46.
3. Dong M, et al. Cancer Chemother Pharmacol. 2012 Jun;69(6):1413-22.
4. Gao S, et al. Anticancer Agents Med Chem. 2017;17(6):802-812.
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