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Cyclo(-RGDfK)
CAS No. 161552-03-0
Cyclo(-RGDfK)( Cyclo(RGDfK) peptide | Cyclic RGDfK peptide )
Catalog No. M12350 CAS No. 161552-03-0
A RGD pipetide, potent and selective αvβ3 integrin inhibitor with Kd of 41.7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 50 | In Stock |
|
| 5MG | 90 | In Stock |
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| 10MG | 163 | In Stock |
|
| 25MG | 308 | In Stock |
|
| 50MG | 494 | In Stock |
|
| 100MG | 577 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCyclo(-RGDfK)
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NoteResearch use only, not for human use.
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Brief DescriptionA RGD pipetide, potent and selective αvβ3 integrin inhibitor with Kd of 41.7 nM.
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DescriptionA RGD pipetide, potent and selective αvβ3 integrin inhibitor with Kd of 41.7 nM; shows strong inhibitory effect on the proliferation of T-24 cells; induces less tumor progression, less tumor metabolic activity, fewer intratumoral vessels in mice model.(In Vitro):Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with a IC50 of 0.94 nM. [66Ga]DOTA-E-[c(RGDfK)]2 can be prepared with high radiochemical purity (>97%), specific activity (36-67GBq/μM), in vitro stability, and moderate protein binding. MicroPET imaging up to 24 post-injection showed contrasting tumors reflecting αvβ3-targeted tracer accumulation.
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In VitroCyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with a IC50 of 0.94 nM. [66Ga]DOTA-E-[c(RGDfK)]2 can be prepared with high radiochemical purity (>97%), specific activity (36-67GBq/μM), in vitro stability, and moderate protein binding. MicroPET imaging up to 24 post-injection showed contrasting tumors reflecting αvβ3-targeted tracer accumulation.
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In Vivo——
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SynonymsCyclo(RGDfK) peptide | Cyclic RGDfK peptide
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PathwayCell Cycle/DNA Damage
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TargetIntegrin
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RecptorαVβ3integrin
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number161552-03-0
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Formula Weight603.6705
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Molecular FormulaC27H41N9O7
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Purity>98% (HPLC)
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SolubilityDMSO: ≥150 mg/mL
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SMILESC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CCCCN)CC2=CC=CC=C2)CC(=O)O
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Chemical NameCyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-lysyl)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sancey L, et al. Mol Ther. 2009, 17(5), 837-843.
2. Zhou D, et al. J Control Release. 2013, 169(3), 204-210.
3. Vilchis-Juarez A, et al. J Biomed Nanotechnol. 2014 Mar;10(3):393-404.
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