PRN371( PRN 371 )

Catalog No. M12331 CAS No. 1610974-55-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PRN371
Note

Research use only, not for human use.
Brief Description

PRN371 is a novel potent, selective JAK3 inhibitor with IC50 of 0.5 nM.
Description

PRN371 is a novel potent, selective JAK3 inhibitor with IC50 of 0.5 nM, displays >250-fold selectivity over JAK1, JAK2, and TYK2; effectively inhibits IL-2 induces JAK1/3-STAT5 phosphorylation in PBMCs with IC50 of 99 nM, effectively blocks JAK3-mediated signaling in JAK3-driven cancer cells; effectively inhibits the growth of NKTL cells via suppressing the JAK3-STAT pathway, and exhibits a more durable inhibition on JAK3 compared to tofacitinib in vitro; significantly inhibits tumor growth in NKTL xenograft model harboring JAK3 activating mutation.
In Vitro

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In Vivo

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Synonyms

PRN 371
Pathway

Angiogenesis
Target

JAK
Recptor

JAK
Research Area

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Indication

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CAS Number

1610974-55-4
Formula Weight

363.421
Molecular Formula

C20H21N5O2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

2-(3-acrylamidophenyl)-N-(tert-butyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

1. Nairism?gi M-, et al. Leukemia. 2018 Feb 2. doi: 10.1038/s41375-017-0004-x.

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