ML316( ML 316 )

Catalog No. M12305 CAS No. 1604819-70-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ML316
Note

Research use only, not for human use.
Brief Description

ML316 is a specific antifungal agent that fungal-selectively inhibits the mitochondrial phosphate carrier Mir1.
Description

ML316 is a specific antifungal agent that fungal-selectively inhibits the mitochondrial phosphate carrier Mir1, exhibits potent antifungal activity against the moderatelyazole-resistant C. albicans strain CaCi-2 with MIC of 0.05 ug/ml; kills drug-resistant Candida species at nanomolar concentrations; diminishes mitochondrial oxygen consumption, resulting in an unusual metabolic catastrophe marked by citrate accumulation and death in respiring yeast; reduces fungal burden and enhances azole activity in mouse model of azole-resistant oropharyngeal candidiasis.
In Vitro

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In Vivo

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Synonyms

ML 316
Pathway

Microbiology/Virology
Target

Fungal
Recptor

Fungal
Research Area

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Indication

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CAS Number

1604819-70-6
Formula Weight

350.408
Molecular Formula

C17H19FN2O3S
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

ethyl 1-(4-fluorophenyl)-4-oxo-2-thioxo-1,3-diazaspiro[4.5]decane-3-carboxylate

1. McLellan CA, et al. Nat Chem Biol. 2018 Feb;14(2):135-141.

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