Sodium cromoglicate

Research use only, not for human use.

Sodium cromoglicate is a mast cell stabilizer with anti-inflammatory activity that prevents the release of inflammatory chemicals such as histamine, leukotrienes from mast cells.

Sodium cromoglicate is a mast cell stabilizer with anti-inflammatory activity that prevents the release of inflammatory chemicals such as histamine, leukotrienes from mast cells; also inhibits chloride channels, and binds S100P to block the interaction between S100P and RAGE.Psoriasis Phase 3 Clinical(In Vitro):Cromolyn sodium (Disodium Cromoglycate; FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack. (In Vivo):Pretreatment of IIR mice with Cromolyn sodium (Disodium Cromoglycate; FPL-670) prior to ischemia exhibited no changes of ET-1 levels, injury score and inflammation (P>0.05, PreCr vs. M groups). In conclusion, administration of Cromolyn (sodium) after reperfusion, but not prior to ischemia, attenuates IIRI by downregulating ET-1 and suppressing sustained MC activation. Cromolyn (sodium) has a role in the prevention of Chronic lung disease(CLD). Cromolyn (sodium) cannot be recommended for the prevention of CLD in preterm infants.

Cromolyn sodium (Disodium Cromoglycate; FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.

Pretreatment of IIR mice with Cromolyn sodium (Disodium Cromoglycate; FPL-670) prior to ischemia exhibited no changes of ET-1 levels, injury score and inflammation (P>0.05, PreCr vs. M groups). In conclusion, administration of Cromolyn (sodium) after reperfusion, but not prior to ischemia, attenuates IIRI by downregulating ET-1 and suppressing sustained MC activation. Cromolyn (sodium) has a role in the prevention of Chronic lung disease(CLD). Cromolyn (sodium) cannot be recommended for the prevention of CLD in preterm infants.

Cromolyn sodium | PA-101 | FPL-670 | Disodium cromoglicate

Others

Other Targets

PotassiumChannel|ProteinS100-P

Inflammation/Immunology

Psoriasis

15826-37-6

512.334

C23H14Na2O11

>98% (HPLC)

water: 25.6 mg/mL (50 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

[Na+].OC(COC1=C2C(=O)C=C(OC2=CC=C1)C(O)=O)COC1=C2C(=O)C=C(OC2=CC=C1)C(O)=O

5,5'-((2-hydroxypropane-1,3-diyl)bis(oxy))bis(4-oxo-4H-chromene-2-carboxylic acid)

(-20℃)

With Ice Pack

≥ 2 years