RO6889678( RO 6889678 )

Catalog No. M12255 CAS No. 1578153-27-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

RO6889678
Note

Research use only, not for human use.
Brief Description

RO6889678 is a highly potent inhibitor of HBV capsid formation with attributes that are favorable for targeting the liver, whilst maintaining moderate peripheral exposure.
Description

RO6889678 is a highly potent inhibitor of HBV capsid formation with attributes that are favorable for targeting the liver, whilst maintaining moderate peripheral exposure.HBV InfectionPhase 1 Discontinued.
In Vitro

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In Vivo

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Synonyms

RO 6889678
Pathway

Microbiology/Virology
Target

HBV
Recptor

HBV
Research Area

Infection
Indication

HBV Infection

CAS Number

1578153-27-1
Formula Weight

494.922
Molecular Formula

C21H20ClFN4O5S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C([C@H]1N(CC2=C(C(OC)=O)[C@H](C3=CC=C(F)C=C3Cl)N=C(C4=NC=CS4)N2)CCOC1)O
Chemical Name

(S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid

1. Kratochwil NA, et al. J Pharmacol Exp Ther. 2018 Feb 16. pii: jpet.117.245712.

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