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Dofequidar fumarate

CAS No. 153653-30-6

Dofequidar fumarate( MS-209 )

Catalog No. M12171 CAS No. 153653-30-6

A novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 92 In Stock
2MG 44 In Stock
5MG 73 In Stock
10MG 121 In Stock
25MG 245 In Stock
50MG 462 In Stock
100MG 672 In Stock
200MG Get Quote In Stock
500MG 1414 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Dofequidar fumarate
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.
  • Description
    A novel, orally active quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR; completely reverses resistance against vincristine in vitro in multidrug-resistant variants of mouse leukemia P388 cells and human leukemia K562 cells at 1-10 uM; greatly reduces the SP-derived tumor growth in vivo combined with CPT-11.Breast cancer Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    MS-209
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    P-glycoprotein
  • Recptor
    P-glycoprotein
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    153653-30-6
  • Formula Weight
    597.6576
  • Molecular Formula
    C34H35N3O7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 56 mg/mL
  • SMILES
    C1CN(CCN1CC(COC2=CC=CC3=C2C=CC=N3)O)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5.C(=CC(=O)O)C(=O)O
  • Chemical Name
    Ethanone, 1-[4-[2-hydroxy-3-(5-quinolinyloxy)propyl]-1-piperazinyl]-2,2-diphenyl-, (2E)-2-butenedioate (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nakanishi O, et al. Oncol Res. 1997;9(2):61-9. 2. Sato W, et al. Cancer Chemother Pharmacol. 1995;35(4):271-7. 3. Katayama R, et al. Cancer Sci. 2009 Nov;100(11):2060-8.
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