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Nalfurafine

CAS No. 152657-84-6

Nalfurafine( TRK-820 | TRK820 )

Catalog No. M12134 CAS No. 152657-84-6

Nalfurafine (TRK-820, TRK820) is potent, selective agonist of kappa-opioid receptor with Ki of 3.5 nM, 15-fold less potent for μOR and little affinity for δOR (Ki=53 and 1,200 nM, respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 354 Get Quote
10MG 527 Get Quote
25MG 845 Get Quote
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Biological Information

  • Product Name
    Nalfurafine
  • Note
    Research use only, not for human use.
  • Brief Description
    Nalfurafine (TRK-820, TRK820) is potent, selective agonist of kappa-opioid receptor with Ki of 3.5 nM, 15-fold less potent for μOR and little affinity for δOR (Ki=53 and 1,200 nM, respectively).
  • Description
    Nalfurafine (TRK-820, TRK820) is potent, selective agonist of kappa-opioid receptor with Ki of 3.5 nM, 15-fold less potent for μOR and little affinity for δOR (Ki=53 and 1,200 nM, respectively); also potently binds to mutant κ(E297K), μ(K303E), κ(E297W) and κ(E297A) with Ki of 10-50 nM; inhibits forskolin-stimulated intracellular cAMP accumulation with IC50 of 0.15 nM, which is 100 fold smaller than that of U69593; produces potent antinociceptive effects in vivo.Other Indication Approved.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TRK-820 | TRK820
  • Pathway
    Endocrinology/Hormones
  • Target
    Opioid Receptor
  • Recptor
    Opioid Receptor
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    152657-84-6
  • Formula Weight
    476.5641
  • Molecular Formula
    C28H32N2O5
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CN(C1CCC2(C3CC4=C5C2(C1OC5=C(C=C4)O)CCN3CC6CC6)O)C(=O)C=CC7=COC=C7
  • Chemical Name
    2-Propenamide, N-[(5α,6β)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-, (2E)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nagase H, et al. Chem Pharm Bull (Tokyo). 1998 Feb;46(2):366-9. 2. Seki T, et al. Eur J Pharmacol. 1999 Jul 2;376(1-2):159-67. 3. Endoh T, et al. Life Sci. 1999;65(16):1685-94. 4. Endoh T, et al. Eur J Pharmacol. 2000 Jan 10;387(2):133-40.
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