ACT-541468( Nemorexant | ACT541468 | DORA )

Catalog No. M12099 CAS No. 1505484-82-1

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Product Name

ACT-541468
Note

Research use only, not for human use.
Brief Description

A potent, selective, dual orexin receptor 1 and 2 (OX1 and OX2) antagonist with Kb of 0.52 and 0.78 nM, respectively.
Description

A potent, selective, dual orexin receptor 1 and 2 (OX1 and OX2) antagonist with Kb of 0.52 and 0.78 nM, respectively; displays high selectivity over a panel of 130 central and peripheral pharmacological targets; shows potential for treatment of insomnia disorder.Sleep Disorder Phase 2 Clinical
In Vitro

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In Vivo

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Synonyms

Nemorexant | ACT541468 | DORA
Pathway

GPCR/G Protein
Target

Orexin Receptor
Recptor

Orexin Receptor
Research Area

Neurological Disease
Indication

Sleep Disorder

CAS Number

1505484-82-1
Formula Weight

450.927
Molecular Formula

C23H23ClN6O2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 250 mg/mL 554.42 mM
SMILES

O=C(N1[C@](C)(C2=NC3=C(C)C(Cl)=CC=C3N2)CCC1)C4=CC(OC)=CC=C4N5N=CC=N5
Chemical Name

(S)-(2-(5-chloro-4-methyl-1H-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

1. Treiber A, et al. J Pharmacol Exp Ther. 2017 Sep;362(3):489-503.

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