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Clemastine fumarate
CAS No. 14976-57-9
Clemastine fumarate( —— )
Catalog No. M12078 CAS No. 14976-57-9
Clemastine Fumarate is a selective histamine H1 receptor antagonist with IC50 of 3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 34 | In Stock |
|
| 100MG | 46 | In Stock |
|
| 200MG | 68 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameClemastine fumarate
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NoteResearch use only, not for human use.
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Brief DescriptionClemastine Fumarate is a selective histamine H1 receptor antagonist with IC50 of 3 nM.
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DescriptionClemastine Fumarate is a selective histamine H1 receptor antagonist with IC50 of 3 nM. (In Vitro):Vorinostat efficiently suppresses MES-SA cell growth at a low dosage (3 μM) already after 24 hours treatment. HDACs class I (HDAC2 and 3) as well as class II (HDAC7) are preferentially affected by this treatment. Vorinostat significantly increases p21WAF1 expression and apoptosis in MES-SA cells.Vorinostat inhibits SK-N-SH and SK-N-Be(2)C with the IC25 values of 1 μM and 0.5 μM, respectively.Vorinostat is an effective inhibitor of HPV-18 DNA amplification, reduces oncoproteins E6 and E7 activities and triggers apoptosis in HPV-infected, differentiated cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetHistamine Receptor
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RecptorH1 receptor
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number14976-57-9
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Formula Weight459.97
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Molecular FormulaC25H30ClNO5
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Purity>98% (HPLC)
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SolubilityDMSO: 35 mg/mL warmed (76.09 mM)
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SMILESC[C@@](C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCC[C@H]3CCCN3C.C(=C/C(=O)O)\C(=O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Seifert R, et al. Mol Pharmacol, 1992, 42(2), 227-234.
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