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Pregabalin
CAS No. 148553-50-8
Pregabalin( CI-1008 | S-(+)-3-isobutylgaba )
Catalog No. M12048 CAS No. 148553-50-8
Pregabalin (CI-1008) is a 3-isobutyl derivative of GABA that selectively binds to alpha2delta (A2D) subunit voltage-dependent calcium channels (VDCCs).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePregabalin
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NoteResearch use only, not for human use.
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Brief DescriptionPregabalin (CI-1008) is a 3-isobutyl derivative of GABA that selectively binds to alpha2delta (A2D) subunit voltage-dependent calcium channels (VDCCs).
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DescriptionPregabalin (CI-1008) is a 3-isobutyl derivative of GABA that selectively binds to alpha2delta (A2D) subunit voltage-dependent calcium channels (VDCCs); prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation.Epilepsy Approved.
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In Vitro——
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In Vivo——
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SynonymsCI-1008 | S-(+)-3-isobutylgaba
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorCalcium Channel
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Research AreaNeurological Disease
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IndicationEpilepsy
Chemical Information
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CAS Number148553-50-8
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Formula Weight159.23
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Molecular FormulaC8H17NO2
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)C[C@H](CN)CC(O)=O
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Chemical Name(S)-3-(Aminomethyl)-5-methylhexanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Field MJ, et al. Br J Pharmacol. 1997 Aug;121(8):1513-22.
2. Field MJ, et al. J Pharmacol Exp Ther. 1997 Sep;282(3):1242-6.
3. Eutamene H, et al. J Pharmacol Exp Ther. 2000 Oct;295(1):162-7.
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