K-Ras G12C-IN-12( MDK-7958 | MDK7958 | MDK 7958 | K-Ras(G12C) inhibitor 12 )

Catalog No. M12005 CAS No. 1469337-95-8

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Product Name

K-Ras G12C-IN-12
Note

Research use only, not for human use.
Brief Description

An allosteric inhibitor of oncogenic K-Ras(G12C) with EC50 of 0.32 uM in H1792 cells.
Description

An allosteric inhibitor of oncogenic K-Ras(G12C) with EC50 of 0.32 uM in H1792 cells; relys on the mutant cysteine for binding and therefore do not affect the wild-type K-Ras.
In Vitro

——
In Vivo

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Synonyms

MDK-7958 | MDK7958 | MDK 7958 | K-Ras(G12C) inhibitor 12
Pathway

MAPK/ERK Signaling
Target

Ras
Recptor

K-Ras(G12C)
Research Area

Cancer
Indication

——

CAS Number

1469337-95-8
Formula Weight

449.6713
Molecular Formula

C15H17ClIN3O3
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 48 mg/mL
SMILES

C=CC(N1CCN(C(CNC2=CC(I)=C(Cl)C=C2O)=O)CC1)=O
Chemical Name

2-Propen-1-one, 1-[4-[2-[(4-chloro-2-hydroxy-5-iodophenyl)amino]acetyl]-1-piperazinyl]-

1. Ostrem JM, et al. Nature. 2013 Nov 28;503(7477):548-51.

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