Cart
sales@molnova.com
ETX2514
CAS No. 1467157-21-6
ETX2514( ETX 2514 | ETX-2514 )
Catalog No. M12003 CAS No. 1467157-21-6
ETX2514 (ETX 2514, ETX-2514) is a covalent, broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A KPC-2, class C AmpC and class D OXA-24, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 264 | In Stock |
|
| 5MG | 403 | In Stock |
|
| 10MG | 592 | In Stock |
|
| 25MG | 888 | In Stock |
|
| 50MG | 1242 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameETX2514
-
NoteResearch use only, not for human use.
-
Brief DescriptionETX2514 (ETX 2514, ETX-2514) is a covalent, broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A KPC-2, class C AmpC and class D OXA-24, respectively.
-
DescriptionETX2514 (ETX 2514, ETX-2514) is a covalent, broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A KPC-2, class C AmpC and class D OXA-24, respectively; potently inhibit clinically relevant class A, C and D β-lactamases and penicillin-binding proteins, resulting in intrinsic antibacterial activity against Enterobacteriaceae and restoration of β-lactam activity in a broad range of MDR Gram-negative pathogens; demonstrates potent antibacterial activity, in vivo efficacy against MDR A. baumannii infections combined with sulbactam.Bacterial Infection Phase 1 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsETX 2514 | ETX-2514
-
PathwayGPCR/G Protein
-
TargetAntibacterial
-
RecptorAntibacterial
-
Research AreaInfection
-
IndicationBacterial Infection
Chemical Information
-
CAS Number1467157-21-6
-
Formula Weight299.233
-
Molecular FormulaC8H10N3NaO6S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC1=CC2CN(C1C(=O)N)C(=O)N2OS(=O)(=O)[O-].[Na+]
-
Chemical Namesodium (2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl sulfate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Durand-Réville TF, et al. Nat Microbiol. 2017 Jun 30;2:17104.
2. Shapiro AB, et al. ACS Infect Dis. 2017 Nov 10;3(11):833-844.
3. McLeod SM, et al. Antimicrob Agents Chemother. 2017 Nov 13. pii: AAC.01576-17.
molnova catalog
related products
-
ANT431
ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2.
-
Grosvenorine
Grosvenorine exhibits good antibacterial and antioxidant activities, with its metabolites possessing more potent activities.
-
Crebanine
Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rata.
