RUSKI-201( RUSKI 201 | RUSKI201 )

Catalog No. M11977 CAS No. 1458031-48-5

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Product Name

RUSKI-201
Note

Research use only, not for human use.
Brief Description

A potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM.
Description

A potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM; blocks Hh signaling in H520, Panc-1, and MCF-7 coculture with Shh-Light2 cells (IC50=4.8 uM, 7.8 uM, and 8.5 uM, respectively); selectively inhibits Hh palmitoylation over a panel of >100 palmitoylated substrates in cells.
In Vitro

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In Vivo

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Synonyms

RUSKI 201 | RUSKI201
Pathway

GPCR/G Protein
Target

Hedgehog (Hh)
Recptor

Hedgehog (Hh)
Research Area

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Indication

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CAS Number

1458031-48-5
Formula Weight

357.516
Molecular Formula

C20H27N3OS
Purity

>98% (HPLC)
Solubility

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SMILES

CC1=CC=CC(C2C(C=CS3)=C3CCN2C(CNCC(C)CC)=O)=N1
Chemical Name

1-[6,7-Dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]ethanone

1. Rodgers UR, et al. ACS Chem Biol. 2016 Dec 16;11(12):3256-3262.

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