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Mitiglinide calcium
CAS No. 145525-41-3
Mitiglinide calcium( KAD-1229 | S-21403 )
Catalog No. M11966 CAS No. 145525-41-3
An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | In Stock |
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| 200MG | 37 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMitiglinide calcium
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NoteResearch use only, not for human use.
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Brief DescriptionAn insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells.
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DescriptionAn insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells; has potent hypoglycemic effects.Diabetes Approved.
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In VitroMitiglinide Calcium inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 value, 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells.
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In VivoMitiglinide Calcium (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load. Animal Model:Pregnant Wistar rats (12 weeks) Dosage:0.3 mg/kg, 1 mg/kg, 3 mg/kg Administration:Oral administration Result:Dose-dependently suppressed AUC glucose levels.
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SynonymsKAD-1229 | S-21403
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorATP-sensitiveK+channels
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Research AreaMetabolic Disease
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IndicationDiabetes
Chemical Information
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CAS Number145525-41-3
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Formula Weight334.44
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Molecular FormulaC19H24NO3Ca0.5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1CCC2CN(CC2C1)C(=O)CC(CC3=CC=CC=C3)C(=O)[O-].C1CCC2CN(CC2C1)C(=O)CC(CC3=CC=CC=C3)C(=O)[O-].[Ca+2]
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Chemical Name2H-Isoindole-2-butanoic acid, octahydro-γ-oxo-α-(phenylmethyl)-, calcium salt (2:1), (αS,3aR,7aS)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ohnota H, et al. J Pharmacol Exp Ther. 1994 May;269(2):489-95.
2. Ohnota H, et al. Biochem Pharmacol. 1995 Jan 18;49(2):165-71.
3. Kinukawa M, et al. Br J Pharmacol. 1996 Apr;117(8):1702-6.
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