GDC-0927 racemate( GDC0927 racemate )

Catalog No. M11883 CAS No. 1443983-36-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GDC-0927 racemate
Note

Research use only, not for human use.
Brief Description

GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) for treatment of metastatic hormone receptor-positive/HER2-negative breast cancer.
Description

GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) for treatment of metastatic hormone receptor-positive/HER2-negative breast cancer.
In Vitro

GDC-0927 Racemate (Example 1) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases. GDC-0927 Racemate reduces the viability of MCF7 cells with an IC50 of 0.21 nM.
In Vivo

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Synonyms

GDC0927 racemate
Pathway

Endocrinology/Hormones
Target

Estrogen Receptor/ERR
Recptor

Estrogen Receptor/ERR
Research Area

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Indication

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CAS Number

1443983-36-5
Formula Weight

461.533
Molecular Formula

C28H28FNO4
Purity

>98% (HPLC)
Solubility

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SMILES

OC1=CC=C2C(C(C)=C(C3=CC=CC(O)=C3)C(C4=CC=C(OCCN5CC(CF)C5)C=C4)O2)=C1
Chemical Name

2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol