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SAR131675
CAS No. 1433953-83-3
SAR131675( —— )
Catalog No. M11844 CAS No. 1433953-83-3
AR131675 is highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 60 | Get Quote |
|
| 10MG | 104 | Get Quote |
|
| 25MG | 214 | Get Quote |
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| 50MG | 326 | Get Quote |
|
| 100MG | 489 | Get Quote |
|
| 200MG | 588 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSAR131675
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NoteResearch use only, not for human use.
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Brief DescriptionAR131675 is highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases.
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DescriptionAR131675 is highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. However, it is moderately active on VEGFR-2 with a VEGFR-3/VEGFR-2 ratio of about 10. SAR131675 inhibits VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC50 values of 20 and 45 nM, respectively.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetVEGFR
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RecptorVEGFR
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1433953-83-3
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Formula Weight358.39
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Molecular FormulaC??H??N?O?
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Purity>98% (HPLC)
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SolubilityN/A
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SMILESO=C1C(C(NC)=O)=C(N)N(CC)C2=NC(C#C[C@@](COC)(C)O)=CC=C21
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Alam A, et al. SAR131675, a potent and selective VEGFR-3-TK inhibitor with antilymphangiogenic, antitumoral, and antimetastatic activities. Mol Cancer Ther. 2012 Aug;11(8):1637-49.
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