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GSK-2878175
CAS No. 1423007-82-2
GSK-2878175( GSK2878175 | GSK8175 | GSK-175 | GSK-175A )
Catalog No. M11780 CAS No. 1423007-82-2
GSK-2878175 (GSK-175, GSK-175A) is a potent, pan-genotypic, second generation HCV NS5B polymerase inhibitor with EC50 of 0.4-9.7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1593 | Get Quote |
|
| 50MG | 3222 | Get Quote |
|
| 100MG | 4410 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGSK-2878175
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NoteResearch use only, not for human use.
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Brief DescriptionGSK-2878175 (GSK-175, GSK-175A) is a potent, pan-genotypic, second generation HCV NS5B polymerase inhibitor with EC50 of 0.4-9.7 nM.
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DescriptionGSK-2878175 (GSK-175, GSK-175A) is a potent, pan-genotypic, second generation HCV NS5B polymerase inhibitor with EC50 of 0.4-9.7 nM; exhibited low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons, displayed a 60-63 h half-life and a robust decrease in viral RNA levels in HCV infected patients relative to GSK5852.HCV Infection Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsGSK2878175 | GSK8175 | GSK-175 | GSK-175A
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PathwayMicrobiology/Virology
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TargetHCV
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RecptorHCV
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Research AreaInfection
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IndicationHCV Infection
Chemical Information
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CAS Number1423007-82-2
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Formula Weight568.807
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Molecular FormulaC27H23BClFN2O6S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=C(C2=CC=C(F)C=C2)OC3=CC(N(C4=CC(Cl)=C5C(COB5O)=C4)S(=O)(C)=O)=C(C6CC6)C=C13)NC
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Chemical Name6-[N-(7-chloro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methanesulfonamido]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gardner SD, et al. J Viral Hepat. 2018 Jan;25(1):19-27.
2.?Chong PY, et al. J Med Chem. 2019 Feb 14. doi: 10.1021/acs.jmedchem.8b01719.
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