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Zolmitriptan
CAS No. 139264-17-8
Zolmitriptan( BW 311C90 | Zomig )
Catalog No. M11634 CAS No. 139264-17-8
Zolmitriptan is a selective serotonin receptor agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 30 | In Stock |
|
| 50MG | 28 | In Stock |
|
| 100MG | 45 | In Stock |
|
| 200MG | 72 | In Stock |
|
| 500MG | 137 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameZolmitriptan
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NoteResearch use only, not for human use.
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Brief DescriptionZolmitriptan is a selective serotonin receptor agonist.
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DescriptionZolmitriptan is a selective serotonin receptor agonist.(In Vitro):Zolmitriptan (311C90) exhibits higher affinity to 5-HT than sumatriptan (pKA=6.63±0.04 and 6.16±0.03, respectively). 311C90 displays high affinity at human recombinant 5-HT1D and 5-HT1B receptors in transfected CHO-K1 cell membranes (pIC50 values=9.16±0.12 and 8.32±0.09, respectively) .(In Vivo):Zolmitriptan (311C90; 3-30 μg/kg, i.v.) causes a dose-dependent inhibition of [125I]-albumin extravasation within the ipsilateral dura mater. Zolmitriptan also produces dose-dependent falls in cranial vascular conductance (32.3% at 30 μg/kg). Zolmitriptan is an anti-migraine agent with action at 5-HT1B/D receptors. Zolmitriptan is an effective and behaviorally specific anti-aggressive agent in situations that engender moderate and alcohol-heightened levels of aggression. Zolmitriptan (1-30 mg/kg, i.p.) exerts behaviorally specific anti-aggressive effects in mice."
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In VitroZolmitriptan (311C90) exhibits higher affinity to 5-HT than sumatriptan (pKA=6.63±0.04 and 6.16±0.03, respectively). 311C90 displays high affinity at human recombinant 5-HT1D and 5-HT1B receptors in transfected CHO-K1 cell membranes (pIC50 values=9.16±0.12 and 8.32±0.09, respectively) .
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In VivoZolmitriptan (311C90; 3-30 μg/kg, i.v.) causes a dose-dependent inhibition of [125I]-albumin extravasation within the ipsilateral dura mater. Zolmitriptan also produces dose-dependent falls in cranial vascular conductance (32.3% at 30 μg/kg).Zolmitriptan is an anti-migraine agent with action at 5-HT1B/D receptors. Zolmitriptan is an effective and behaviorally specific anti-aggressive agent in situations that engender moderate and alcohol-heightened levels of aggression. Zolmitriptan (1-30 mg/kg, i.p.) exerts behaviorally specific anti-aggressive effects in mice. Animal Model:Anaesthetized guinea-pigs.
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SynonymsBW 311C90 | Zomig
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number139264-17-8
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Formula Weight287.36
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Molecular FormulaC16H21N3O2
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Purity>98% (HPLC)
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SolubilityEthanol: 58 mg/mL (201.83 mM); DMSO: 58 mg/mL (201.83 mM)
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SMILESO=C1OC[C@H](CC2=CC3=C(NC=C3CCN(C)C)C=C2)N1
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Chemical Name(4S)-4-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-1,3-oxazolidin-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Le Grand B, et al. Eur J Pharmacol. 2000 Jun 2;397(2-3):297-302.
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