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EMA300
CAS No. 136676-76-1
EMA300( PD121981 )
Catalog No. M11515 CAS No. 136676-76-1
EMA300 (PD1 21981) is a potent, selective small molecule antagonist of angiotensin II type 2 receptor (AT2R).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameEMA300
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NoteResearch use only, not for human use.
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Brief DescriptionEMA300 (PD1 21981) is a potent, selective small molecule antagonist of angiotensin II type 2 receptor (AT2R).
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DescriptionEMA300 (PD1 21981) is a potent, selective small molecule antagonist of angiotensin II type 2 receptor (AT2R) with >1,000-fold selectivity over AT1 receptor, produces analgesia in rodent model of neuropathic pain.
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In Vitro——
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In Vivo——
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SynonymsPD121981
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PathwayGPCR/G Protein
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TargetAngiotensin Receptor
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RecptorAngiotensin Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number136676-76-1
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Formula Weight495.579
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Molecular FormulaC30H29N3O4
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name1H-Imidazo[4,5-c]pyridine-6-carboxylic acid, 5-(diphenylacetyl)-4,5,6,7-tetrahydro-1-[(4-methoxy-3-methylphenyl)methyl]-, (S)- (9CI)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Losartan
A selective, competitive angiotensin II receptor type 1 (AT1) antagonist (IC50=20 nM) for treatment of high blood pressure (hypertension).
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Angiotensin II (1-4)...
Angiotensin II is a potent direct vasoconstrictor, causing arteries and veins to constrict, so leading to an increase in blood pressure. Angiotensin also potentiates the release of norepinephrine by a direct action on postganglionic sympathetic fibers.
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Brain Natriuretic Pe...
Brain Natriuretic Peptide (BNP) (1-32), rat is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes).Brain natriuretic peptide (type B natriuretic peptide) was originally isolated from brain, but is mainly produced in myoendocrine cells of the heart ventricles from which it is released into the circulation.
