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YH239-EE
CAS No. 1364488-67-4
YH239-EE( YH 239-EE | YH 239 EE )
Catalog No. M11502 CAS No. 1364488-67-4
YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 95 | In Stock |
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| 5MG | 57 | In Stock |
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| 10MG | 91 | In Stock |
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| 25MG | 188 | In Stock |
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| 50MG | 343 | In Stock |
|
| 100MG | 511 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameYH239-EE
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NoteResearch use only, not for human use.
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Brief DescriptionYH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM.
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DescriptionYH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM, shows no affinity for MDM4; induces apoptosis in AML cells and patient samples, induces p53 and activates the apoptotic caspase 3/7 in MOLM-13 (wt-p53) cells.
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In Vitro——
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In Vivo——
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SynonymsYH 239-EE | YH 239 EE
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PathwayApoptosis
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TargetMDM2-p53
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Recptorp53/MDM2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1364488-67-4
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Formula Weight504.4056
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Molecular FormulaC25H27Cl2N3O4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 55 mg/mL
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SMILESO=C(C(N1)=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(NC(C)(C)C)=O)C3=C1C=C(Cl)C=C3)OCC
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Chemical Name1H-Indole-2-carboxylic acid, 6-chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-, ethyl ester
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Huang Y, et al. ACS Chem Biol. 2014 Mar 21;9(3):802-11.
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