YH239-EE( YH 239-EE | YH 239 EE )

Catalog No. M11502 CAS No. 1364488-67-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

YH239-EE
Note

Research use only, not for human use.
Brief Description

YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM.
Description

YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM, shows no affinity for MDM4; induces apoptosis in AML cells and patient samples, induces p53 and activates the apoptotic caspase 3/7 in MOLM-13 (wt-p53) cells.
In Vitro

——
In Vivo

——
Synonyms

YH 239-EE | YH 239 EE
Pathway

Apoptosis
Target

MDM2-p53
Recptor

p53/MDM2
Research Area

Cancer
Indication

——

CAS Number

1364488-67-4
Formula Weight

504.4056
Molecular Formula

C25H27Cl2N3O4
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 55 mg/mL
SMILES

O=C(C(N1)=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(NC(C)(C)C)=O)C3=C1C=C(Cl)C=C3)OCC
Chemical Name

1H-Indole-2-carboxylic acid, 6-chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-, ethyl ester

1. Huang Y, et al. ACS Chem Biol. 2014 Mar 21;9(3):802-11.

Calculator

molnova catalog