Cart
sales@molnova.com
YH239-EE
CAS No. 1364488-67-4
YH239-EE( YH 239-EE | YH 239 EE )
Catalog No. M11502 CAS No. 1364488-67-4
YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 95 | In Stock |
|
| 5MG | 57 | In Stock |
|
| 10MG | 91 | In Stock |
|
| 25MG | 188 | In Stock |
|
| 50MG | 343 | In Stock |
|
| 100MG | 511 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameYH239-EE
-
NoteResearch use only, not for human use.
-
Brief DescriptionYH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM.
-
DescriptionYH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM, shows no affinity for MDM4; induces apoptosis in AML cells and patient samples, induces p53 and activates the apoptotic caspase 3/7 in MOLM-13 (wt-p53) cells.
-
In Vitro——
-
In Vivo——
-
SynonymsYH 239-EE | YH 239 EE
-
PathwayApoptosis
-
TargetMDM2-p53
-
Recptorp53/MDM2
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number1364488-67-4
-
Formula Weight504.4056
-
Molecular FormulaC25H27Cl2N3O4
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 55 mg/mL
-
SMILESO=C(C(N1)=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(NC(C)(C)C)=O)C3=C1C=C(Cl)C=C3)OCC
-
Chemical Name1H-Indole-2-carboxylic acid, 6-chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-, ethyl ester
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Huang Y, et al. ACS Chem Biol. 2014 Mar 21;9(3):802-11.
molnova catalog
related products
-
Nutlin-3a
The active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay.
-
RETRA hydrobromide
RETRA hydrobromide is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft.
-
CP-31398 dihydrochlo...
CP-31398 is a small molecule p53 reactivator that protects p53 from thermal denaturation.
