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ML-210
CAS No. 1360705-96-9
ML-210( ML 210 | ML210 )
Catalog No. M11484 CAS No. 1360705-96-9
A small-molecule probe that selectively kills cells induced to express mutant RAS; inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 79 | In Stock |
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| 2MG | 42 | In Stock |
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| 5MG | 75 | In Stock |
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| 10MG | 136 | In Stock |
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| 25MG | 246 | In Stock |
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| 50MG | 405 | In Stock |
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| 100MG | 546 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameML-210
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NoteResearch use only, not for human use.
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Brief DescriptionA small-molecule probe that selectively kills cells induced to express mutant RAS; inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM.
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DescriptionA small-molecule probe that selectively kills cells induced to express mutant RAS; inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM, displays 23-fold sensitivity over BJeH-LT (isogenic to BJeLR without HRAS G12V) cell lines; a useful tool for identifying oncogene-specific pathways and targets in cancer cells.
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In Vitro——
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In Vivo——
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SynonymsML 210 | ML210
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PathwayMAPK/ERK Signaling
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TargetRas
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RecptorRas
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Research Area——
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Indication——
Chemical Information
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CAS Number1360705-96-9
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Formula Weight475.32
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Molecular FormulaC22H20Cl2N4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (52.60 mM)
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SMILESO=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C4=NOC(C)=C4[N+]([O-])=O
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Chemical Name(4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. We?wer M, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6.
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