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XZH-5
CAS No. 1360562-98-6
XZH-5( XZH5 )
Catalog No. M11481 CAS No. 1360562-98-6
XZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameXZH-5
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NoteResearch use only, not for human use.
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Brief DescriptionXZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation.
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DescriptionXZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation, inhibits STAT3 DNA binding ability and downregulation of STAT3 downstream genes; inhibits downregulation of STAT3 downstream genes, such as Bcl-2, Bcl-xL, Cyclin D1 and Survivin, demonstrates blockade of STAT3 phosphorylation in human rhabdomyosarcoma cells with apoptosis and suppresses colony-forming ability and cell migration; blocks IL-6-induced STAT3 phosphorylation and nuclear translocation but not the stimulation of STAT1 phosphorylation by IFN-γ.
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In Vitro——
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In Vivo——
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SynonymsXZH5
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorSTAT
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Research Area——
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Indication——
Chemical Information
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CAS Number1360562-98-6
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Formula Weight537.463
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Molecular FormulaC22H25F6N5O4
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(OC)[C@@H](N(NC(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)C(CC(C)C)=O)CC2=CN(C)C=N2
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Chemical Namemethyl Na-(((3,5-bis(trifluoromethyl)phenyl)carbamoyl)-L-valyl)-Nt-methyl-L-histidinate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Liu Y, et al. Apoptosis. 2011 May;16(5):502-10.
2. Liu A, et al. Cancer Sci. 2011 Jul;102(7):1381-7.
3. Liu A, PLoS One. 2012;7(10):e46624.
4. Daka P, et al. Bioorg Med Chem. 2015 Mar 15;23(6):1348-55.
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