ML165( RUC-2 | ML 165 )

Catalog No. M11454 CAS No. 1355454-05-5

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Product Name

ML165
Note

Research use only, not for human use.
Brief Description

A high-affinity, selective platelet integrin αIIbβ3 receptor antagonist with IC50 of 96 nM.
Description

A high-affinity, selective platelet integrin αIIbβ3 receptor antagonist with IC50 of 96 nM; specifically inhibits ligand binding by a novel mechanism, leading to loss of the MIDAS metal ion while producing only minor changes in the conformation of β3.
In Vitro

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In Vivo

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Synonyms

RUC-2 | ML 165
Pathway

Cell Cycle/DNA Damage
Target

Integrin
Recptor

Integrin
Research Area

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Indication

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CAS Number

1355454-05-5
Formula Weight

385.446
Molecular Formula

C17H19N7O2S
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C1=CC=C(C=C1)F)NC2=CC(=CC(=N2)NC3=NC=CN=C3)C4=CN(N=C4)C.C(=CC(=O)O)C(=O)O
Chemical Name

2-amino-N-(3-(5-oxo-7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl)phenyl)acetamide

1. Zhu J, et al. Sci Transl Med. 2012 Mar 14;4(125):125ra32. 2. Jiang JK, et al. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1148-53.

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