YLC2-155( YLC 2-155 | YLC2155 )

Catalog No. M11447 CAS No. 1354742-60-1

YLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

YLC2-155
Note

Research use only, not for human use.
Brief Description

YLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT.
Description

YLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT; binds at the RNase H (RNH)-active site in multiple conformations; demonstrates inhibition of fully infectious HIV-1 (strain NL4-3) with EC50 of 6.7 uM in cell-based assays.
In Vitro

——
In Vivo

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Synonyms

YLC 2-155 | YLC2155
Pathway

Microbiology/Virology
Target

HIV
Recptor

HIV
Research Area

——
Indication

——

Chemical Information

CAS Number

1354742-60-1
Formula Weight

243.22
Molecular Formula

C13H9NO4
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

7-(furan-2-yl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Kirby KA, et al. Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01351-17. 2. Kirby KA, et al. Antimicrob Agents Chemother. 2012 Apr;56(4):2048-61.

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