Cart
sales@molnova.com
YLC2-155
CAS No. 1354742-60-1
YLC2-155( YLC 2-155 | YLC2155 )
Catalog No. M11447 CAS No. 1354742-60-1
YLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameYLC2-155
-
NoteResearch use only, not for human use.
-
Brief DescriptionYLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT.
-
DescriptionYLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT; binds at the RNase H (RNH)-active site in multiple conformations; demonstrates inhibition of fully infectious HIV-1 (strain NL4-3) with EC50 of 6.7 uM in cell-based assays.
-
In Vitro——
-
In Vivo——
-
SynonymsYLC 2-155 | YLC2155
-
PathwayMicrobiology/Virology
-
TargetHIV
-
RecptorHIV
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1354742-60-1
-
Formula Weight243.22
-
Molecular FormulaC13H9NO4
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name7-(furan-2-yl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kirby KA, et al. Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01351-17.
2. Kirby KA, et al. Antimicrob Agents Chemother. 2012 Apr;56(4):2048-61.
molnova catalog
related products
-
MK-2048
MK-2048 is a potent inhibitor of HIV-1 integrase (IN) and IN mutant R263K with IC50 of 2.6 nM and 1.5 nM, respectively.
-
Indinavir sulfate
Indinavir is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM.
-
DMJ-I-228
A small molecule CD4-mimetic that binds gp120 and blocks CD4 binding, inhibits HIV-1 entry with IC50 of 86.9 uM.
