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GSK-583
CAS No. 1346547-00-9
GSK-583( GSK583 | GSK 583 )
Catalog No. M11400 CAS No. 1346547-00-9
A potent, selective and orally bioavailable RIPK2 kinase inhibitor with IC50 of 5 nM and 2 nM for human and rat RIP2, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 2MG | 60 | In Stock |
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| 5MG | 88 | In Stock |
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| 10MG | 123 | In Stock |
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| 25MG | 217 | In Stock |
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| 50MG | 296 | In Stock |
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| 100MG | 407 | In Stock |
|
| 200MG | 592 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK-583
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and orally bioavailable RIPK2 kinase inhibitor with IC50 of 5 nM and 2 nM for human and rat RIP2, respectively.
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DescriptionA potent, selective and orally bioavailable RIPK2 kinase inhibitor with IC50 of 5 nM and 2 nM for human and rat RIP2, respectively; displays robust selectivity against p38α and VEGFR2, and shows little or no inhibition of RIP3-dependent necroptotic cell death; potently and dose dependently inhibits MDP-stimulated TNFα production in human monocytes and human whole bolld with IC50 of 8 nM and 237 nM, respectively; inhibits MDP-induced inflammatory responses in vivo.
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In Vitro——
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In Vivo——
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SynonymsGSK583 | GSK 583
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PathwayApoptosis
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TargetRIP kinase
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RecptorRIP1|RIP3
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1346547-00-9
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Formula Weight398.4539
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Molecular FormulaC20H19FN4O2S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 37 mg/mL
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SMILESFC1=CC2=C(NN=C2NC3=CC=NC4=CC=C(S(=O)(C(C)(C)C)=O)C=C34)C=C1
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Chemical Name4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Haile PA, et al. J Med Chem. 2016 May 26;59(10):4867-80.
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