Home - Products - Apoptosis - RIP kinase - Sibiriline

Sibiriline

CAS No. 1346526-26-8

Sibiriline( Sibiriline )

Catalog No. M11395 CAS No. 1346526-26-8

A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
5MG	873	Get Quote
50MG	1782	Get Quote
100MG	2250	Get Quote
200MG	Get Quote	Get Quote
500MG	Get Quote	Get Quote
1G	Get Quote	Get Quote

Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

Sibiriline
Note

Research use only, not for human use.
Brief Description

A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3.
Description

A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3; inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2 uM); selectively inhibits necroptotic cell death induced by various death ligands in human or mouse cells while not protecting from caspase-dependent apoptosis; protects mice from concanavalin A-induced hepatitis.
In Vitro

——
In Vivo

——
Synonyms

Sibiriline
Pathway

Apoptosis
Target

RIP kinase
Recptor

RIP kinase
Research Area

——
Indication

——

Chemical Information

CAS Number

1346526-26-8
Formula Weight

210.236
Molecular Formula

C13H10N2O
Purity

>98% (HPLC)
Solubility

——
SMILES

OC1=CC=C(C2=CC3=CC=CN=C3N2)C=C1
Chemical Name

4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Le Cann F, et al. FEBS J. 2017 Jul 17. doi: 10.1111/febs.14176.

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

related products

GSK-872

GSK-872 (GSK 872) is a potent and selective RIPK3 (receptor-interacting protein kinase-3) inhibitor.
GSK-2982772

GSK-2982772 is a potent, selective, ATP competitive RIP1 kinase inhibitor with IC50 of 16 nM.
RIPK1-IN-4

RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase).

Sign In Join Free