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AU-1235

CAS No. 1338780-86-1

AU-1235( AU1235 )

Catalog No. M11362 CAS No. 1338780-86-1

AU-1235 is a novel, specific mycobacterial membrane protein large 3 (MmpL3) inhibitor.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	168	In Stock
2MG	93	In Stock
5MG	188	In Stock
10MG	293	In Stock
25MG	493	In Stock
50MG	700	In Stock
100MG	986	In Stock
200MG	Get Quote	In Stock
500MG	1972	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

AU-1235
Note

Research use only, not for human use.
Brief Description

AU-1235 is a novel, specific mycobacterial membrane protein large 3 (MmpL3) inhibitor.
Description

AU-1235 is a novel, specific mycobacterial membrane protein large 3 (MmpL3) inhibitor with MIC of 0.1 ug/mL (0.3 uM) against Mtb H37Rv.
In Vitro

AU1235 is similarly active against MDR isolates of M. tb displaying resistance to isoniazid, rifampicin, and pyrazinamide in addition to streptomycin, fluoroquinolones and/or ethambutol. AU1235 also inhibits Mycobacterium smegmatis and Mycobacterium fortuitum although the MICs (3.2 to 6.4 μg/ml) are significantly higher than against M. tb and M. bovis BCG.
In Vivo

——
Synonyms

AU1235
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

Chemical Information

CAS Number

1338780-86-1
Formula Weight

324.347
Molecular Formula

C17H19F3N2O
Purity

>98% (HPLC)
Solubility

DMSO : 6 mg/mL 18.50 mM
SMILES

C1C2CC3CC1CC(C2)(C3)NC(=O)NC4=C(C(=C(C=C4)F)F)F
Chemical Name

N-Tricyclo[3.3.1.13,7]dec-1-yl-N'-(2,3,4-trifluorophenyl)urea

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Grzegorzewicz AE, et al. Nat Chem Biol. 2012 Feb 19;8(4):334-41. 2. Stanley SA, et al. ACS Chem Biol. 2012 Aug 17;7(8):1377-84.

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