Glufosfamide

Research use only, not for human use.

A conjugate of glucose and active alkylating moiety of ifosfamide with potentially enhanced selectivity for tumors that overexpress transmembrane glucose transporters.

A conjugate of glucose and active alkylating moiety of ifosfamide with potentially enhanced selectivity for tumors that overexpress transmembrane glucose transporters; has the better cell permeability than ifosfamide; Glufosfamide utilizes the normal cell glucose transport mechanism (SAAT1) for transport into the cell, enhances the activity of gemcitabine in vitro and in vivo.Pancreatic Cancer Phase 3 Clinical.

——

——

D-19575 | D19575

Cell Cycle/DNA Damage

DNA Alkylator

DNA Alkylator

Cancer

Pancreatic Cancer

132682-98-5

383.16

C10H21Cl2N2O7P

>98% (HPLC)

In Vitro:?H2O : 125 mg/mL (326.23 mM)

O=P(NCCCl)(NCCCl)O[C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O

N,N'-Bis(2-chloroethyl)phosphorodiamidic acid beta-D-glucopyranosyl ester

(-20℃)

With Ice Pack

≥ 2 years