Cart
sales@molnova.com
JAK1-IN-31
CAS No. 1315498-72-6
JAK1-IN-31( —— )
Catalog No. M11278 CAS No. 1315498-72-6
JAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameJAK1-IN-31
-
NoteResearch use only, not for human use.
-
Brief DescriptionJAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM.
-
DescriptionJAK1-IN-31 is a potent and selective JAK1 inhibitor with Ki of 1.9 nM, less potent for JAK3 (Ki=280 nM) and Tyk2 (Ki=12 nM) and no inhibition on hERG and CYP3A4 (IC50>10 uM); exhibits favorable oral bioavailability across a range of preclinical species and robust efficacy in a rat CIA model.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayAngiogenesis
-
TargetJAK
-
RecptorJAK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1315498-72-6
-
Formula Weight449.529
-
Molecular FormulaC23H23N5O3S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Nametrans-4-(2-((R)-1-Hydroxyethyl)-6-(phenylsulfonyl)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexanecarbonitrile
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Zak M, et al. J Med Chem. 2013 Jun 13;56(11):4764-85.
molnova catalog
related products
-
Izencitinib
Izencitinib (JNJ-8398) is an orally active and gut-selective JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.
-
WHI-P97 HCl 211555-0...
WHI-P97 HCl is a potent and selective JAK-3 inhibitor.?WHI-P97 had an estimated Ki value of 0.09 microM from modeling studies and a measured IC50 value of 2.5 microM in EGFR kinase inhibition assays.?WHI-P97 effectively inhibited the in vitro invasiveness of EGFR-positive human cancer cells in a concentration-dependent manner.
-
Tofacitinib
Tofacitinib (CP-690550) is a potent, specific, orally active inhibitor of JAK3 with IC50 of 1 nM in cell-free assays; displays 20- to 100-fold less potency for JAK2 and JAK1 (IC50=20 nM and 112 nM, respectively).
