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TMP-269
CAS No. 1314890-29-3
TMP-269( TMP 269 | TMP269 )
Catalog No. M11270 CAS No. 1314890-29-3
A potent and selective class IIa HDAC inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 118 | In Stock |
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| 2MG | 63 | In Stock |
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| 5MG | 92 | In Stock |
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| 10MG | 156 | In Stock |
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| 25MG | 260 | In Stock |
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| 50MG | 459 | In Stock |
|
| 100MG | 555 | In Stock |
|
| 200MG | 799 | In Stock |
|
| 500MG | 1200 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTMP-269
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective class IIa HDAC inhibitor.
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DescriptionA potent and selective class IIa HDAC inhibitor with IC50s of 126/80/36/19 nM for HDAC4/5/7/9; less potent or no inhibition for others HDAC isoforms (>2 uM); prevents cell cycle progression, DNA synthesis, and proliferation induced in response to G protein-coupled receptor/PKD1 activation in IEC-18 cells.
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In Vitro——
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In Vivo——
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SynonymsTMP 269 | TMP269
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC4|HDAC5|HDAC7|HDAC9
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1314890-29-3
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Formula Weight514.5195
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Molecular FormulaC25H21F3N4O3S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 41 mg/mL
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SMILESO=C(NCC1(C2=NC(C3=CC=CC=C3)=CS2)CCOCC1)C4=CC=CC(C5=NOC(C(F)(F)F)=N5)=C4
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Chemical NameBenzamide, N-[[tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lobera M, et al. Nat Chem Biol. 2013 May;9(5):319-25.
2. Sinnett-Smith J, et al. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71.
3. Kikuchi S, et al. Leukemia. 2015 Sep;29(9):1918-27.
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