Cart
sales@molnova.com
TMP-269
CAS No. 1314890-29-3
TMP-269( TMP 269 | TMP269 )
Catalog No. M11270 CAS No. 1314890-29-3
A potent and selective class IIa HDAC inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 118 | In Stock |
|
| 2MG | 63 | In Stock |
|
| 5MG | 92 | In Stock |
|
| 10MG | 156 | In Stock |
|
| 25MG | 260 | In Stock |
|
| 50MG | 459 | In Stock |
|
| 100MG | 555 | In Stock |
|
| 200MG | 799 | In Stock |
|
| 500MG | 1200 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTMP-269
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent and selective class IIa HDAC inhibitor.
-
DescriptionA potent and selective class IIa HDAC inhibitor with IC50s of 126/80/36/19 nM for HDAC4/5/7/9; less potent or no inhibition for others HDAC isoforms (>2 uM); prevents cell cycle progression, DNA synthesis, and proliferation induced in response to G protein-coupled receptor/PKD1 activation in IEC-18 cells.
-
In Vitro——
-
In Vivo——
-
SynonymsTMP 269 | TMP269
-
PathwayCell Cycle/DNA Damage
-
TargetHDAC
-
RecptorHDAC4|HDAC5|HDAC7|HDAC9
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number1314890-29-3
-
Formula Weight514.5195
-
Molecular FormulaC25H21F3N4O3S
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 41 mg/mL
-
SMILESO=C(NCC1(C2=NC(C3=CC=CC=C3)=CS2)CCOCC1)C4=CC=CC(C5=NOC(C(F)(F)F)=N5)=C4
-
Chemical NameBenzamide, N-[[tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Lobera M, et al. Nat Chem Biol. 2013 May;9(5):319-25.
2. Sinnett-Smith J, et al. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71.
3. Kikuchi S, et al. Leukemia. 2015 Sep;29(9):1918-27.
molnova catalog
related products
-
ACY-738
ACY-738 (ACY738) is a potent and specific HDAC6 inhibitor (IC50=1.7 nM) with improved brain bioavailability; displays 60-1500 fold selectivity over class I HDACs.
-
CHR-3996
CHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3.
-
T247
A potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8.
