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Ibulocydine
CAS No. 1314096-68-8
Ibulocydine( Ibulocydine )
Catalog No. M11259 CAS No. 1314096-68-8
Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 963 | Get Quote |
|
| 50MG | 1962 | Get Quote |
|
| 100MG | 2520 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameIbulocydine
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NoteResearch use only, not for human use.
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Brief DescriptionIbulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively.
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DescriptionIbulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively; reduces the phosphorylation of RNA polymerase II at Ser-5 and Ser-2, down-regulates Mcl-1, survivin, and XIAP and induces apoptosis; shows effectivity in HCC xenografts with no toxic side effects.
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In Vitro——
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In Vivo——
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SynonymsIbulocydine
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research Area——
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Indication——
Chemical Information
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CAS Number1314096-68-8
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Formula Weight458.269
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Molecular FormulaC16H20BrN5O6
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(C)C(OC[C@@H]1O[C@H](N2C=NC(N)=C3C2=NC(Br)=C3C(N)=O)[C@@H](O)[C@@H]1O)=O
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Chemical Name((2S,3S,4S,5S)-5-(4-amino-6-bromo-5-carbamoyl-1H-pyrrolo[2,3-d]pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cho SJ, et al. J Biol Chem. 2011 Jun 3;286(22):19662-71.
2. Park SS, et al. Radiother Oncol. 2014 Aug;112(2):295-301.
3. Park SS,, et al. Int J Biochem Cell Biol. 2017 Feb;83:47-55.
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